In chemistry , a phosphorochloridate is a class of organophosphorus compounds with the formula (RO) 2 P(O)Cl (R = organic substituent). They are tetrahedral in shape, akin to regular phosphates (OP(OR) 3 ). They are usually colorless and sensitive toward hydrolysis. They are oxidized derivatives of phosphorochloridites , which have the formula (RO) 2 PCl. A popular example is diethyl phosphorochloridate . Synthesis and reactions Phosphochloridites are precursors to phosphate esters : [ 1 ] Other nucleophiles have been employed, such as azide. [ 2 ] ↑ D. C. Muchmore (1972). "Preparation and Reductive Cleavage of Enol Phosphates: 5-Methylcoprost-3-ene" . Org. Synth . 52 : 109. doi : 10.15227/orgsyn.052.0109 . ↑ Shioiri, Takayuki; Yamada, Shun-ichi (1984). "Diphenyl Phosphorazidate" . Org. Synth . 62 : 187. doi : 10.15227/orgsyn.062.0187 . P 2 O 5 · n H 2 O – OP< free acid HOP(CF 3 ) 2 free acid HOP(CF 3 ) 2 ( – O) 2 PN< e.g. Nucleoside phosphoramidite e.g. Nucleoside phosphoramidite ( – O) 2 P(O)N< e.g. Phosphocreatine e.g. Phosphocreatine – OP(O)(N<) 2 e.g. Morpholino Cyclophosphamide

e.g. Morpholino Cyclophosphamide P(N<) 3 e.g. P(NMe 2 ) 3 e.g. P(NMe 2 ) 3 OP(N<) 3 e.g. Hexamethylphosphoramide Metepa e.g. Hexamethylphosphoramide PS x O 3 − 4- x Organophosphites Functional groups Phosphorus halides Phosphorus(V) compounds Articles with short description Short description matches Wikidata